A Brief Prehistory of Huntington's Disease

A brief prehistory of Huntington's disease.

Physicians and family members alike have long been curious about the historical origins of Huntington’s disease. Despite the fact that families with “hereditary chorea” were described in medical literature for the first time in the 1840s, most authors agree that the genetic abnormality and most likely the panoply of symptoms we know today as Huntington’s disease were present centuries earlier i...

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Chagas disease in prehistory.

The classical hypothesis proposes that Chagas disease has been originated in the Andean region among prehistoric people when they started domesticating animals, changing to sedentary habits, and adopting agriculture. These changes in their way of life happened nearly 6,000 years ago. However, paleoparasitological data based on molecular tools showed that Trypanosoma cruzi infection and Chagas d...

Huntingtin and the molecular pathogenesis of Huntingtons disease

Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease